Week 4 is loaded -- like pretty much every week in college football -- is loaded.

Let's break down some of the marquee Week 4 matchups, with odds from DraftKings Sportsbook as of Sept. 20.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

What to know: Both teams enter Week 4 off convincing wins. Texas Tech rolled Oregon State 45-14, while Utah stifled Wyoming 31-6.

What to know: Auburn stayed unbeaten with a 31-15 win over South Alabama. Oklahoma has held two straight opponents to just three points, including a 42-3 thrashing of Temple.

No. 21 Michigan @ Nebraska (3:30 p.m., CBS)

Point spread: Michigan -1.5 (Michigan favored to win by more than 1.5 points, otherwise Nebraska covers)

Moneyline: Michigan -118 favorite to win; Nebraska -102 underdog to win

Total scoring Over/Under: 47.5 points scored by both teams combined

What to know: Michigan bounced back from its loss to Oklahoma with a 63-3 demolition of Central Michigan. Nebraska is off to a 3-0 start with wins over Cincinnati, Akron and Houston Christian.

South Carolina @ No. 23 Missouri (7:00 p.m., ESPN)

Point spread: Missouri -10 (Missouri favored to win by more than 10 points, otherwise South Carolina covers)

Moneyline: Missouri -340 favorite to win; South Carolina +270 underdog to win

Total scoring Over/Under: 48.5 points scored by both teams combined

What to know: South Carolina, which was ranked No. 11 entering the game, was stunned by Vanderbilt 31-7 in Week 3 and might still be without QB LaNorris Sellers after taking a helmet-to-helmet hit Saturday. Missouri is 3-0 after blowing out Louisiana 52-10.

What to know: Florida has dropped two straight, including a 20-10 loss to LSU. Miami, meanwhile, rolled South Florida 49-12 to move to 3-0.

What to know: Both teams are 3-0 after Week 3 shutouts -- Illinois over Western Michigan, and Indiana over Indiana State.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!

College Football Week 4 Preview: Best Games to Watch This Weekend