BALTIMORE -- With runners on the corners and the Yankees hoping for a two-out rally in the first inning, Giancarlo Stanton drove the 450 home run of his career over Camden Yards' towering right field wall on Saturday night.

The three-run jack sparked the Bombers' offense in a 6-1 win that coincided with the Blue Jays' fourth straight loss. With just seven games left in the regular season, the Yanks are now two games behind Toronto for first place in the American League East.

However, the Jays hold the tiebreaker after going 8-5 against the Yankees this season.

While the Yankees, who hold the top Wild Card spot, gained ground in the standings, Stanton took sole possession of 41 place on the all-time home run list. The designated hitter had previously been tied with Jeff Bagwell and Vladimir Guerrero.

Next up on the all-time list is Carl Yastrzemski, who hit 452 home runs.

Playing in his 1,719 career game, Stanton also became the fifth-fastest player to reach 450 home runs. Only Mark McGwire (1,524 games), Babe Ruth (1,585), Alex Rodriguez (1,684),and Harmon Killebrew (1,713) reached the milestone quicker.

Stanton, who missed the first two months of the season with tennis elbows, now has 21 dingers this year. He's hit those with his lingering elbow issues requiring regular maintenance, and he's added 56 RBI, a .916 OPS and a 150 wRC+ while also returning to the outfield, a move made necessary after Aaron Judge suffered a right flexor strain.

Judge, playing right field for the third straight day but still limiting his throws, also homered on Saturday, crushing a third-inning solo shot off Orioles starter Tomoyuki Sugano for his 49 longball. The 6-7 slugger's average, meanwhile, is up to a major league-leading .329 as he tries to become the tallest batting champ in baseball history.

Judge and Stanton have now homered in the same game 57 times, including the postseason, passing Yogi Berra and Mickey Mantle for the second-most times in franchise history. Only Lou Gehrig and Babe Ruth joined forces more often, homering in the same game 75 times, per the YES Network's Jeff Quagliata.

The Yankees padded their lead some more before the night ended, as Jazz Chisholm Jr. picked up an RBI single in the fifth before Trent Grisham followed suit in the sixth.

Carlos Rodón, meanwhile, continued his run of excellence, permitting just one run over seven innings. The lefty also tallied four hits, one walk and eight strikeouts on his way to his 17 win, a new career-high.

Rodón, who has a 3.04 ERA overall after 32 starts, entered Saturday's game with a 6-2 record and a 2.45 ERA over his last eight starts, as well as a 7-3 record and a 2.80 ERA over his last 12 outings.

The lone run he allowed on Saturday came on a Coby Mayo double in the seventh.

Giancarlo Stanton smashes 450th homer as Yankees gain ground in AL East